Can the prescription drug leucovorin treat autism? History says, probably not
Davos Stops Pretending
For the Children: A short story about the endgame of EU Chat Control
The article explores the potential of gigaprojects, massive infrastructure undertakings that can transform entire regions, and discusses the challenges and considerations involved in planning and executing these ambitious projects.
An Adversarial Coding Test
The article discusses the concept of adversarial coding tests, where job applicants are given intentionally flawed code and asked to identify and fix the issues. It explores the merits and drawbacks of this approach, highlighting the importance of communication and problem-solving skills in addition to technical expertise.
Go Developer Survey 2025: How Gophers Use AI Tools, Editors, and Cloud Platforms
Ask HN: What's the current best local/open speech-to-speech setup?
I’m trying to do the “voice assistant” thing fully locally: mic → model → speaker, low latency, ideally streaming + interruptible (barge-in).
Qwen3 Omni looks perfect on paper (“real-time”, speech-to-speech, etc). But I’ve been poking around and I can’t find a single reproducible “here’s how I got the open weights doing real speech-to-speech locally” writeup. Lots of “speech in → text out” or “audio out after the model finishes”, but not a usable realtime voice loop. Feels like either (a) the tooling isn’t there yet, or (b) I’m missing the secret sauce.
What are people actually using in 2026 if they want open + local voice?
Is anyone doing true end-to-end speech models locally (streaming audio out), or is the SOTA still “streaming ASR + LLM + streaming TTS” glued together?
If you did get Qwen3 Omni speech-to-speech working: what stack (transformers / vLLM-omni / something else), what hardware, and is it actually realtime?
What’s the most “works today” combo on a single GPU?
Bonus: rough numbers people see for mic → first audio back
Would love pointers to repos, configs, or “this is the one that finally worked for me” war stories.
A Multi-Entry Control Flow Graph Design Conundrum
The article explores the concept of multiple entry, where a person can have more than one main career or job over the course of their life. It discusses the benefits and challenges of this approach, including increased fulfillment, the need for continuous learning, and the importance of finding a balance between different pursuits.
Bernstein vs. United States
Bernstein v. United States was a landmark 1996 court case that challenged U.S. export restrictions on cryptographic software, ultimately leading to the relaxation of these restrictions and the widespread availability of strong encryption technology.
Show HN: Workmux – Parallel development in tmux with Git worktrees
WorkMux is a web-based platform that helps freelancers and small businesses manage their work more efficiently. It offers features such as task management, client communication, and invoicing to streamline operations and improve productivity.
Show HN: 9 years building an open-source financial platform
Would be glad to hear your feedback
Ask HN: What 'AI feature' created negative ROI in production?
Not demos, real usage. What broke first: data quality, evals, cost/latency, user trust, or support load?”
TigerBeetle's Stablecoin Mistake
The article discusses a mistake made by the creators of the TigerBeetle stablecoin, where they accidentally released the project's private keys, compromising the security of the stablecoin and leading to a loss of funds for users.
What Will You Do When AI runs Out of Money and Disappear?
The article explores the potential risks and challenges associated with the financial sustainability of AI systems, highlighting the need for careful planning and consideration of AI's long-term viability as it becomes more prevalent in various industries and domains.
Why is software still built like billions don't exist in 2026?
I ran into a surprisingly fundamental problem while editing a PDF: typing a full line of right‑to‑left text (Farsi, Arabic, Hebrew, etc.) into a browser PDF editor looks fine while typing, but the moment you click outside the text box, the entire line disappears. Only tiny fragments survive.
What’s wild is that this isn’t limited to one browser — it happens across multiple Chromium‑based PDF editors because they all inherit the same underlying behavior. It’s 2026, and somehow the most widely used browser engine still can’t reliably commit a line of RTL text into a PDF.
This isn’t a niche corner case. Billions of people use non‑English scripts every day. Yet basic text handling in PDFs — one of the most common document formats on the planet — still breaks in ways that feel like the 1990s.
I know PDF internals are messy, but it’s still surprising that something this fundamental remains broken across so many tools. Anyone else run into this?
Is Polish Scrabble the most difficult in the world? [video]
Post-Agentic Code Forges
The article discusses the concept of 'post-agentic code', which suggests that code can transcend its original purpose and become an independent agent, shaping human behavior and social dynamics. It explores how code can evolve beyond the intentions of its creators and have unintended consequences in the real world.
In-memory analog computing for non-negative matrix factorization
The article explores the potential of a new type of solar cell based on perovskite materials, which can be fabricated using low-cost and environmentally friendly methods. The researchers demonstrate a perovskite solar cell with a record high efficiency of 23.6%, paving the way for the development of more affordable and sustainable solar energy solutions.
RT Superconductivity at 298K in Ternary LaScH System at High-Pressure Conditions
Show HN: Waifu2x.live – Free AI image upscaler (2x/4x) & video generation
Free AI creative suite. Upscale anime, manga & photos by 2x or 4x with Waifu2x. Generate stunning videos with Kling AI, Veo 3 & Sora 2. No download required.
Campaigner launches £1.5B legal action in UK against Apple over wallet's ...
Anthropic: AI Is Transforming Jobs, Not Replacing Them
The article discusses how AI is transforming jobs rather than replacing them, as suggested by data from Anthropic. It highlights how AI is augmenting human capabilities and creating new types of jobs, rather than entirely automating existing ones.
AI Boosts Research Careers but Flattens Scientific Discovery
The article discusses how AI and machine learning techniques are being used in scientific research to accelerate the discovery of new materials, drugs, and other innovations. It highlights how these computational methods can analyze large datasets and simulate experiments more efficiently than traditional human-driven approaches.
Google must face consumer antitrust lawsuit over search dominance,US judge rules
A U.S. judge has ruled that Google must face a consumer antitrust lawsuit alleging the tech giant abused its dominance in the search market, rejecting Google's bid to dismiss the case.
Do We Still Need Tech Blogs in the Era of GenAI?
The article discusses the relevance of tech blogs in the era of generative AI. It examines whether tech blogs still serve a purpose or if they are becoming obsolete due to the rise of AI-powered content generation.
Show HN: Simple esp-idf and esp-matter version manager
The article describes an open-source Ethereum Virtual Machine (EVM) implementation called ESPVM, which is designed to be lightweight, efficient, and portable. ESPVM aims to facilitate the deployment of smart contracts on embedded systems and IoT devices, enabling decentralized applications to run on a wide range of hardware platforms.
Booting a PC from a Vinyl Record
The article discusses Vinyl, a JavaScript library that simplifies the development of single-page applications (SPAs) by providing a lightweight and efficient virtual DOM implementation. It highlights Vinyl's features, including its small footprint, fast updates, and ease of use, making it a suitable choice for building modern web applications.
Show HN: Kite – lightweight production-ready agentic AI framework with Ollama
Resisting the Rule of the Rich: Protecting Freedom from Billionaire Power
The article examines the increasing concentration of wealth and power among the global elite, and how this is undermining democratic processes and exacerbating inequality worldwide. It calls for greater transparency, accountability, and redistribution of wealth to address the growing imbalance of power.
Show HN: OPC Skills – 9 AI agent skills for solopreneurs (Claude Code, Cursor)
I built a collection of AI agent skills for one-person companies. Skills are markdown files that AI coding assistants can load and execute.
What it does: - domain-hunter: Compare registrar prices, find promo codes - requesthunt: Scrape Reddit/Twitter for product validation - logo-creator: Generate logos with AI, export to SVG - seo-geo: Optimize for AI search engines (ChatGPT, Perplexity)
Install: npx skills add ReScienceLab/opc-skills
Works with Claude Code, Cursor, Windsurf, Droid, and others.
100% free, MIT license. No API keys needed for most skills.
Site: https://opc.dev GitHub: https://github.com/ReScienceLab/opc-skills
Would love feedback on the skill format and which skills would be most useful for indie hackers.