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I've been frustrated by existing "magic mushroom dosage calculators": most are either visually rough, only handle cubensis, or hard-code one potency value and ignore species, tolerance, and degradation.

So I built Mycodosing.wtf – a research‑informed calculator that tries to do three things better:

Models species‑level potency using psilocybin/psilocin/baeocystin mg/g with separate profiles for truffles (and syntetics!).

Outputs dose ranges (min/median/max) instead of a single magic number, using per‑species uncertainty factors for real‑world variability.

Includes a tolerance model based on 5‑HT2A receptor downregulation (dose‑dependent exponential decay over ~14 days), plus optional weight adjustment and MAOI flag.

The species potencies are pulled and normalized from LC‑MS/MS and classic chemistry papers (e.g., Garcia‑Romeu 2021, Gotvaldová 2021, Gartz/Stríbrný), then wrapped in a neobrutalist UI built with Vite + React. 100% client-side.

I'd love feedback on:

The dose model itself (any flaws in the math or assumptions?) Species data you'd adjust or supplement What you'd want from a v2

Site: https://mycodosing.wtf/ Code: https://github.com/ing-norante/mycodosing.wtf/

800M people use ChatGPT and Claude weekly. Right now they get text responses. Soon they'll get real interfaces: product cards, blog posts, booking flows, payment screens rendered directly in the conversation.

We built an open-source component library for this. Install any block with one command and customize it to your brand.

If you're building MCP servers or experimenting with AI-native apps, this might save you time.

Are you building apps for AI assistants? Would love to hear what's missing in your workflow.

The article discusses the use of decimal numbers in the US Census, tracing their history and evolution over time. It highlights the practical considerations and challenges in adopting decimal notation for census data collection and reporting.

George Orwell's six rules for effective writing emphasize clarity, simplicity, and concision, advising writers to avoid unnecessary jargon, clichés, and passive voice while being direct and honest in their expression.

Researchers are developing a vaccine that could prevent fentanyl overdoses, which have become a major public health crisis in the United States. The vaccine is about to undergo its first large-scale human clinical trial, with the goal of providing protection against the deadly synthetic opioid.

The article explores how teenagers may interact with AI chatbots and social media platforms in 2025, highlighting trends such as increased reliance on chatbots for emotional support and a shift towards more private, encrypted social media usage among young people.

The article discusses the LangChain-AI/langsmith-fetch project, which is a library that provides a simple way to fetch data from various sources using a consistent API. The library aims to make it easier for developers to integrate data fetching into their applications.

The article discusses the increasing use of AI-powered digital assistants, known as 'copilots', in the workplace. It explores the growth and adoption of these technologies, as well as the implications for productivity, collaboration, and the future of work.

Hey HN, I'm Emir - one of the co-creators of Sim (https://sim.ai/), an open-source [https://github.com/simstudioai/sim/] visual editor to build agentic workflows.

You can run Sim locally using Docker, with no execution limits or other restrictions.

We started building Sim almost a year ago after repeatedly troubleshooting why our agents failed in production. Code-first frameworks felt hard to debug because of implicit control flow, and workflow platforms added more overhead than they removed. We wanted granular control and easy observability without piecing everything together ourselves.

We launched Sim [1][2] as a drag-and-drop canvas around 6 months ago. Since then, we've added:

- 138 blocks: Slack, GitHub, Linear, Notion, Supabase, SSH, TTS, SFTP, MongoDB, S3, Pinecone, ...

- Tool calling with granular control: forced, auto

- Agent memory: conversation memory with sliding window support (by last n messages or tokens)

- Trace spans: detailed logging and observability for nested workflows and tool calling

- Native RAG: upload documents, we chunk, embed with pgvector, and expose vector search to agents

- Workflow deployment versioning with rollbacks

- MCP, Human-in-the-loop blocks

- Copilot to build workflows using natural language (just shipped a new version that also acts as a superagent and can call into any of your connected services directly, not just build workflows)

Under the hood, the workflow is a DAG with concurrent execution by default. Nodes run as soon as their dependencies (upstream blocks) are satisfied. Loops (for, forEach, while, do-while) and parallel fan-out/join are also first-class primitives.

Agent blocks are pass-through to the provider. You pick your model (OpenAI, Anthropic, Gemini, Ollama, vLLM), and and we pass through prompts, tools, and response format directly to the provider API. We normalize response shapes for block interoperability, but we're not adding layers that obscure what's happening.

We're currently working on our own MCP server and the ability to deploy workflows as MCP servers. Would love to hear your thoughts and where we should take it next (:

[1] https://news.ycombinator.com/item?id=43823096

[2] https://news.ycombinator.com/item?id=44052766

Repo: https://github.com/simstudioai/sim

Docs: https://docs.sim.ai

Try it: https://sim.ai

The state of Texas filed an antitrust lawsuit against Epic Systems, a major provider of electronic health records software, alleging that the company engaged in anti-competitive practices to maintain its market dominance and limit consumer choice in the healthcare technology industry.

NopSCADlib is a collection of OpenSCAD modules and functions for designing 3D printable parts. It provides a comprehensive set of components and utilities to aid in the creation of a wide range of 3D printed projects.

The article profiles Ryan Serhant, one of the top real estate agents in New York City, focusing on his rise to success in the competitive Manhattan market and his innovative approach to marketing luxury properties.

The dotenv-diff library allows developers to easily compare and merge environment variables between different .env files, making it a useful tool for managing configuration settings across different environments.

The article explores the development of an intelligent tutoring system to support student learning in programming courses. It discusses the design, implementation, and evaluation of the system, which aims to provide personalized feedback and guidance to students as they learn to code.

The CEO of South Korean e-commerce company Coupang has resigned following a data breach that affected millions of customers. The resignation comes amidst growing scrutiny over the company's data security practices.

The article explores Andrej Karpathy's journey from his early work on deep learning to his current role as the leader of Tesla's Autopilot team. It highlights his key contributions to the field of machine learning and his thoughts on the future of autonomous vehicles.

A new study finds that humans rank among the leading monogamous mammals, with a high rate of pair-bonding and parental care compared to other species. The research provides insights into the evolution of social and mating behaviors in humans.

The article discusses the potential challenges and opportunities presented by the rise of artificial intelligence (AI) and automation in the workplace. It explores the impact on job markets, economies, and the need for policy adaptations to address the societal implications of these technological advancements.

The article provides an overview of the current status of HashiCorp's services, including the status of their various products and any ongoing incidents or maintenance activities that may be affecting them.

Warehouse worker here – I only come up with ideas and architecture, no coding. The code is a minimal AI-generated PoC. Fork / build / comment if you want to help – I handle design, community handles code.

CIX is a deterministic, human-readable indexing system for LLM sessions. It solves drift, staleness and navigation by anchoring events to a stable temporal index.

Repo → https://github.com/VikingFlow/continuous-index Follow → @VikingFlowAI Support → https://ko-fi.com/vikingflowai

The article discusses how artificial intelligence (AI) has the potential to democratize access to powerful tools and resources, empowering individuals and small organizations to compete with larger entities. It explores the ways in which AI can level the playing field and create new opportunities for innovation and entrepreneurship.

The article discusses the Linux MCP (Microcontroller Platform) Server, a tool that allows users to monitor various system metrics and health indicators on their Fedora systems, providing a comprehensive view of the system's performance and status.