What we look for in a resume
No one reads resumes. At best they skim them. They look at the shortest lines, which are usually where you worked and the job title. Name recognition makes a difference here, no matter how many people tell you otherwise. This applies to your college as well. But don't let it discourage you, it's more of a "if you have a big name there you get a boost but it's not a negative if you don't".
They skim for key technologies and then read the text around them.
They most likely will read the full text of the most recent job, so make sure that is the most detailed and interesting.
Your resume should talk about results. Don't say "Created a new CMS for the company". Say "Created a new CMS for the company in Python that resulted in an ~70% reduction in website update times, from 1 hour to 18 minutes."
If you do put a "skills cloud" on it, be ready to talk about them all. If someone had a skills cloud I would immediately look for the most esoteric skills and dive deep on it in the interview (after Googling it myself) to see if you were BSing or not. If you really know that skill, you should know more than what I learned in five minutes of searching.
All this applies to your LinkedIn as well, which you should keep up to date, so that if there is a job you want but don't want to spend the time applying, you can just send them your LinkedIn. :)
Edit: Forgot to mention, as pointed out below, that your resume also drives the interview, so while some of what you write won't be read to get the interview, you still want it there as a place to jump off during an interview. Always better if you can drive the conversation towards your most positive qualities, which is easier if they are in your resume and the interviewer asks about them.